L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.
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Really, really excellent book on the use of Big Data in today's connected world. Author investigates policing, incarceration, schools, marketing, and the political process from the perspective of a data scientist who has seen how algorithms are used with unintended consequences. I especially like her push for the use of big data for justice and benefit to society instead of all the nefarious purposes it is put to now. Easy read.
The adjustments on the rod does not work because you cannot get them on or off the rod due to the 90 degree bends on the rod. Adjustment rod is basically useless.
I can say I used this years ago, warning. If you are a plumber or pipefitter do NOT use this on cutter wheels for a tool that you cut pipe with and then solder. I ended up having a blowout because of this crap in a 2 million dollar apartment. It has a really high temp rating. So if this gets on your pipe you might as well start over by cutting the joint or coupler out or look for a new job ;)
First of all, I am African-American and I swear by this stuff... along with the Joico Silk Result shampoo and conditioner, this allows me to stretch out time until my next relaxer on my 4a/4b textured hair. My hair is kinky, thick-wiry, and I have very dry scalp. This helps smooth down my hair weightlessly and infuse into it cationic hydration and botanical/marine moisturizers- not mineral oil as a cheap filler.