L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • John Scullen - Frommers Italy

    Although a paperback, this travel book is a bit too thick for easy perusing. If I had been in a bookstore I would have realized how cumbersome it was. The info is good, but I'm disappointed in the size.

  • Schadenfreude - Not for those who need intensive math review

    The only reason this book is not getting two stars is that the online component was helpful in preparing for the GRE. I needed this book for the math; however, it's not a strong math review. The practice sets in the book were much easier than what I encountered on test day. There was not nearly enough geometry review - woefully inadequate. I suppose the same could be said for algebra, but I had just done an Algebra CLEP review and didn't need this book for algebra. So if you need a cursory verbal review and an in-depth math review, this is not the prep book for you.

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    I used this product for a few months and at first I was feeling really good, but after the month wore off I had to take more and more and it seemed like a constant expensive circle

  • Amazon Customer - Kleeger Inflatable Baby Water Play Mat is a fun item for my 5 month old grandson

    Kleeger Inflatable Baby Water Play Mat is a fun item for my 5 month old grandson. It is well made and has such a cute ocean theme with the seashells and fish. My grandson loves slapping on the fish which makes them move around in the water and therefore he slaps at them even more. This is a great tummy time play mat, but make sure you are always with a little one while doing tummy time. I really recommend this play mat for your own child, grandchild or as a gift.