L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • Elizabeth - very happy with the purchase

    We have been using the camera now for a few weeks to mostly record my daughter's HS soccer games and other children and family performances and outings. It has worked wonderfully so far. The zoom works well for me. I have only used it on a monopod/tripod, so I cannot say how well the stability control works when using it in your hand. I am very happy with the purchase and would recommend this camera

  • Flipper - Excellent car seat - big and comfy but svelte!

    Despite being fairly large, heavily built, and loaded with padding, the Clek Fllo is one of the narrowest carseats on the market, and is easy to install as well. We liked this seat so much we now own two of them, one for each car. Amazingly, we were able to install this into the center position of our 2009 Toyota Corolla. Despite this being a fairly large seat and the Corolla being a small car, the back of the seat is contoured such that the driver and passenger seats can be moved all the way back without lifting the front of the Fllo up.

  • Luke_M - Good product,but lied to

    This is not a bad product. Its quite functional for the price. However, one side of the watch band broke off and i have to glue it. Also, the seller lied to me. I asked if this watch supported android wear apps, the seller themsleves answered and told me it did. I get the product, and i find that it does not, and that it cannot connect to wifi. I enjoy the product, however i dont appreciate being lied to by the seller. Also, if you want an android wear smart watch, i reccomend a moto 360. Not this. Its a good product for the price,but try to find it through another seller.