L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • Hobbyist - I think it Works

    My 2001 Honda Civic with 200k miles had a slow power steering leak. I filled it a little above the max line during the late spring/early summer and by December it had leaked below the min line. I went to Wal Mart and picked up a bottle of this. Figured the worst this thing that could happen was it leaked just like it did before. I siphoned out whatever I could from the PS reservoir with a turkey baster I also got from Wal Mart for like $2. I filled it back up with the Lucas until it was about a half inch above the max line. Two months later and I don't believe it has leaked anything. So far so good. Had I not added it, the fluid would probably be at the Max line or below by now.

  • lüph - Excellent lights - sturdy and bright!

    Excellent lights - sturdy and bright! Even though I am the sunshine state, I had to put them along the driveway so I got some tree shade, but they still last for a few hours before going out, shining nicely. Either an animal or one of my dogs managed to knock off one of the tops so a better locking mechanism would be nice for country homes but that's not a big deal - the light still works and the casing did not break. I love the steel pole as in the past I had lights like that and their plastic poles broke pretty fast. Definitely recommend!

  • Mkod121 - 57 stars

    Ah this book!!!! I loved it. I felt all of the feels right along with these characters. The writing was perfect as usual and the chemistry between Misha and Ryen was off the charts. Highly recommend!!!!!

  • talang - at first I thought this stuff was a fluke, ...

    at first I thought this stuff was a fluke, but after allowing the engine to run for another 30 minutes (from the required time needed) i saw the white smoke coming from the tailpipe go from minimal to none which allowed me to allocate my money and time elsewhere on my vehicle.