L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • R. Seward - It helped to quiet my water pump.

    I was thinking about replacing the noisy water pump in my travel trailer; but it works fine, and I hate to replace a product that's still working, so I decided to give this a try. It did quiet it down some, but it defiantly didn't silence it. I still get some hammering effect, but it's less than before, I'll live with it until the pump goes out, then I'll invest in a truly silent pump. In fairness, I didn't expect it to completely silence the pump, and it worked about how I expected it to.

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