L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.
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**First of all, as a disclaimer, I want to state that I recently purchased TWO DIFFERENT HESI guides, and they were both fantastic books, but I can't remember which one had which material in it, and since I'm writing these reviews while at work, away from the books, I'm just having to guess. Both books covered basically the same stuff, so even if I am technically reviewing the OTHER book (which I hope very much that I am not!) this book was just as good as that one, so the review could really work for either. Ha. Sorry, I realized that is very disjointed and doesn't make a ton of sense. Either way, this guide is good. I know that for a fact because BOTH of the HESI guides that I purchased were good. So even if I am reviewing the wrong book, I can accurately say that they are both great guides. Now, on to the review.**
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