L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • Daniel Files - Didn't help me at all

    No difference in my hair, and I was trying this stuff religiously for close to 200 days before giving up. Good luck if you try this out as well.

  • momofthree - Made my hair soft, but heavy

    My reason for 4 stars will not be because of packaging. I received this item in a brown envelope and the conditioner spilled all over. The box was soggy. I was surprised because I have purchased many other Keeva products and all have shipped perfectly. Other than that, I did like the product, but I felt like it left my hair feeling heavy. My hair did feel soft and smelled great. Maybe I have not used it enough, but those were the results of the first use. I will update my review after I try it a couple more times. I did receive this item for free for an honest review and it is honest. Thanks for reading.

  • Stephen - Doesn't do it for us

    We tried it out for the 60 day trial period and it didn't overwhelm us to keep it for $130. We asked for a refund.

  • brandeeno - no problems, install was easy

    does what it does. i installed with a screw driver (no torque monitoring) and it works fine. I was not able to tell if i got the direction right on these (forward facing)... the instructions said its important, but i cannot tell. I have a 2012 honda.

  • Jeanni Gould - A Life-saver

    Nature's Miracle works. It's that simple and that great. In addition to puppy training time, I had a dog with bladder cancer. As she began having accidents, I stocked up on Nature's Miracle and was essentially stress free about the carpet.

  • Hubby - No Toe Room

    I'm not sure it's small because of the m(I think means "medium") or not but I was happy to get my shoes. Put them on and my toes are squoozed together. No room to spread my toes. It seams narrow in the toes area. So I thought the show just needed to be worn and broken in. A week and a half later.....it's the same! Of course by that time, I can't return the shoes. I'm not mad. Just disappointed because the shoes look GOOD! I can only wear them a shirt time per day. 😔