L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • Mandie - Lots of great songs and fun dances

    Lots of great songs and fun dances.perfect for a rainy day or when my children cannot go outside due to the heat possibly causing issues with their asthma. Even my husband who was reluctant to play had fun. Great exercise (my legs were sore for days) and fun for our family.

  • Nerdy book lover - Dare #sigh 😍😍😍

    Dare is one of my favorite books of 2016 I totally recommend this series. The love and loyalty Dare gives to his friends and family is one of a kind. Ayda has suffered so much and she is literally scared for life she thinks she will never find love and a happily ever after. This story is amazing!