L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

slamo.biochem.dal.ca Review:

Slamovits Lab @ Dalhousie University |  - We are in the Department of Biochemistry and Molecular Biology at Dalhousie University in Halifax, Nova Scotia Our research interests are related with molecular biology and evolution of eukaryotes and their genomes. In particular, we are interested in studying how genomes and cells evolve as a result of radical changes in lifestyle such as the […]

  • http://slamo.biochem.dal.ca/research/ Slamovits Lab @ Dalhousie University |  Research - Our main research interests are Evolution and structure of the nuclear genomes of dinoflagellate protists Biology and evolution of apicomplexan parasites Evolution of eukaryotic organelles of endosymbiotic origin (mitochondria and chloroplasts) Genomics of Haplosporidia Collaborations We are also working in collaboration with these people: ANdrew Roger (Dalhousie), Mary Beth Saffo and Christopher Lane (University of Rhode Island), […]
  • http://slamo.biochem.dal.ca/research/dinoflagellate-biology-and-evolution/ Slamovits Lab @ Dalhousie University |  Dinoflagellate biology and evolution - DINOFLAGELLATES These critters are among the lab’s favourites. They exhibit many fascinating features and also lots of questions. Our research focuses mainly on their genes and genomes, in the context of the evolution of alveolates, the eukaryotic group dinoflagellates belong in. DINOFLAGELLATE GENOME EVOLUTION OXYRRHIS MARINA FUNCTIONAL GENOMICS Share Tweet wordpress plugins and themes
  • http://slamo.biochem.dal.ca/research/dinoflagellate-biology-and-evolution/oxyrrhis-marina-functional-genomics/ Slamovits Lab @ Dalhousie University |  Oxyrrhis marina Functional Genomics - O. marina functional genomics – The OMFG Project O. marina is a dinoflagellate that lives in marine rocky shores around the world, usually where tide pools form.They are voracious predators: devouring bacteria and other protists seems to be their exclusive activity. O. marina has been used as a model to study various aspects of protist physiology, ecology […]
  • http://slamo.biochem.dal.ca/research/dinoflagellate-biology-and-evolution/genome-biology-of-dinoflagellates/ Slamovits Lab @ Dalhousie University |  Genome evolution in dinoflagellates - Dinoflagellates have very large genomes. So much that the smallest dinoflagellates genomes recorded are about as large as the human genome, whereas the largest are almost 10 times bigger! We don’t know much about them. Not even how many genes or how they are arranged or regulated. Moreover, the way in which DNA is packaged […]
  • http://slamo.biochem.dal.ca/research/biology-and-evolution-of-apicomplexa/ Slamovits Lab @ Dalhousie University |  Biology and evolution of Apicomplexa - APICOMPLEXA is a diverse group of protists that includes thousands of obligate intracellular parasites. Members of this group are known to infect virtually every animal phyla, from land, sea and air. In many cases the relationship between the protist and its host is of relatively peaceful coexistence, but in others things go nasty and the […]
  • http://slamo.biochem.dal.ca/research/biology-of-haplosporidia/ Slamovits Lab @ Dalhousie University |  Biology of Haplosporidia - What is HAPLOSPORIDIA? Haplosporidia is a group of protists (single-celled eukaryotes) that parasitize several kinds of marine invertebrates, including oysters, mussels, clams and crabs. They belong in the eukaryotic supergroup Rhizaria (Cercozoa), but no other details are currently known. It is a relatively small group, with only a handful of known genera, although more species […]
  • http://slamo.biochem.dal.ca/people/ Slamovits Lab @ Dalhousie University |  People - Claudio Slamovits Associate Professor, Dalhousie University PhD – Universidad de  Buenos Aires Postdoc University of British Columbia   Susana A. Breglia Postdoctoral Fellow PhD – University of British Columbia Sergio A. Muñoz Gómez PH.D. Candidate B.Sc. – Universidad de Antioquía, Colombia Donika Shala Biochemistry and Molecular Biology M.Sc. student B.Sc. – St. Mary’s University, Halifax, NS Kassandra Kennedy Dalhousie Biochemistry Honours student Fabian Mejia ELAP Scholar […]
  • http://slamo.biochem.dal.ca/links/ Slamovits Lab @ Dalhousie University |  Links - Online tools and software Databases/sequence/genomes Collaborators and other like-minded groups PipeAlign TranslatorX Treenamer/Refgen MAFFT CIPRES Phylo Portal Parallel Mr. BAYES LTR Finder HMMER PhyML NCBI – Protein Sequence query TBestDB-PepDB (protist ESTs) Eukaryotic Pathogen Database Resource (EuPathDB – Parasites) BLAST @ NCBI B. natans @ JGI JGI-DOE Genomes RepBase EMBL-EBI Genomes GOLD Genomes Online Database Roger […]
  • http://slamo.biochem.dal.ca/publications/ Slamovits Lab @ Dalhousie University |  Publications -   2015.1. Gile, G.H., Moog, D., Slamovits, C.H., Maier, U.G. and Archibald, J.M. 2015. Dual organellar targeting of aminoacyl-tRNA synthetases in diatoms and cryptophytes. Genome Biology and Evolution, in press. Article 2015.Muñoz-Gómez, S.A., Slamovits, C.H., Dacks, J.B., Baier, K.A., Spencer, K.D. and Wideman, J.G. 2015. Ancient homology of the mitochondrial contact site and cristae organizing […]
  • http://slamo.biochem.dal.ca/espanol/ Slamovits Lab @ Dalhousie University |  En Español - Bienvenidos a la página en español del Slamovits Lab! Este laboratorio pertenece a la Facultad De Medicina de la Universidad Dalhousie, ubicada en la ciudad de Halifax, provincia de Nueva Escocia en Canadá. El laboratorio está dirigido por el Dr. Claudio Slamovits, profesor asistente del Departamento de Bioquímica y Biología Molecular desde 2009. ~~ Biografía resumida […]
  • http://slamo.biochem.dal.ca/photos/ Slamovits Lab @ Dalhousie University |  Photos - Laboratory Travel and meetings Halifax and Nova Scotia Share Tweet wordpress plugins and themes

    Country: 129.173.93.207, North America, CA

    City: -63.5822 Nova Scotia, Canada

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