L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.
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I had a leak in my O-ring between my power steering reservoir and the actual pump on my 01 Cherokee Sport. It was leaking pretty badly, and I was having to fill up the fluid almost once a week if not more often. I figured that this stop leak was worth a shot instead of buying a new reservoir or pulling everything out and fixing the leak. I was very surprised to see that after a day of average driving there were no more leaks. So far so good, I have driven about two weeks and 300 some miles and there is no leakage from my Jeep. I am only giving this 4 stars for the time being because I haven't stopped the leak for more than a few weeks, if the reservoir continues to stay dry I will update with another star. A word of warning though, this will not fix leaks in pressure or return hoses, I tried a little of this to try to fix a leak on my high pressure power steering line and it didn't do a thing. For fixing small leaks or drips in the power steering pump/mechanism or rack though this stuff is great.