L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • D. Jester - Good stands, just know their limitations

    Pretty solid for their size, weight, and price. These are not meant for competitive powerlifters, just not that heavy duty. I see they are rated to 390 lbs. I think I would stop at around 315 on them (3- 45 lb./20kg plates on each side of an olympic bar). Also I would not bang a heavy weight against the backstop of them. Use with common sense, and they should be adequate for all but the most serious of home gyms. They are also light enough to put away when not in use.

  • Bookreporter - Fascinating, mesmerizing and very readable

    I was so enchanted with HOMEWARD BOUND that I did something I haven’t done in decades: I listened to the new Paul Simon album (Stranger to Stranger, which is actually pretty good) and dusted off (figuratively, since everything is digital now) the Simon & Garfunkel catalogue, particularly the oh-so-easily-relatable “Fakin’ It.” Who knew, a half-century after the fact, that a three-minute-plus folk-rock song would be even more relevant to at least some people than it was when it was first recorded?

  • Joe MacBu - Ho hum

    While I've enjoyed several other book projects by the Lucky Peach team, I found this one to be kinda dumb. Sure, I appreciate the stupid humor they're sort of going for, but I feel that the culinary part doesn't have much substance. I made several of the recipes and found them to be ho hum. Just uninteresting, boring, blah. They also go for a 70s photo style, which unfortunately does not make the dishes look appetizing.