L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

labblog.uofmhealth.org Review:

Health News, Medical Breakthroughs & Research for Health Professionals - Find the latest health and medical news, medical research and healthcare breakthroughs for healthcare professionals from the University of Michigan Health System.

http://labblog.uofmhealth.org/rounds/to-prep-patients-for-surgery-train-them-like-athletes Surgery Preparation: MSHOP for Patient Preparation Before Surgery - MSHOP seeks to help patients prepare for surgery. Discover how MSHOP encourages patients to exercise, eat a healthy diet, and reduce stress before surgery.

http://labblog.uofmhealth.org/industry-dx/why-doctors-order-scans-for-lower-back-pain-when-they-probably-wont-help Why Doctors Order Scans for Lower Back Pain When They Probably Won’t Help | University of Michigan - http://labblog.uofmhealth.org/sites/lab/files/2016-10/UMH-BackScan-v2-reg%402x%20%281%29.png

http://labblog.uofmhealth.org/rounds/stopped-hearts-need-more-cardiac-arrest-research-to-start Cardiac Arrest Treatment & Post Cardiac Arrest Care Research - Cardiac arrest research is needed, specifically for post cardiac arrest care and cardiac arrest treatment. See the study that details cardiac arrest statistics.

http://labblog.uofmhealth.org/industry-dx/precision-medicine-test-for-breast-cancer-helps-guide-chemotherapy-decisions Precision Medicine: Doctors Using Breast Cancer Genetic Testing - A new study shows that doctors are appropriately using breast cancer genetic testing. Learn more about the 21-gene recurrence score assay and precision medicine.

http://labblog.uofmhealth.org/rounds/can-opioid-overdose-prevention-take-a-lesson-from-stroke-prevention Opioid Overdose & Addiction: Administering Buprenorphine - Buprenorphine could help with preventing opioid overdose & opioid addiction, but it requires heavy doctor oversight. Discover U-M's idea to treat opioid abuse.

http://labblog.uofmhealth.org/med-u/to-achieve-diversity-among-doctors-start-pre-med-years Diversity in Medicine: Physician & Medical School Demographics - U-M program HSSP seeks to help URiM students while they are still in pre-med programs. Learn more about diversity in medicine and medical school demographics.

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