L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.
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The printer itself was a little disappointing. It is slow, and the quality seems so-so unless you use the highest setting. I printed a brochure that had a lot of color on it. It came out with some strange lines in it, which couldn't be seen on the highest print setting, but it looked bad on any other setting. On the highest quality, it printed about one page per minute. The 150 sheet tray couldn't hold more than maybe 120 sheets of thicker paper, and the duplex printing was problematic. I needed to print 600 2-sided sheets, so this was a chore that took all week. The reason I am still giving 4 stars is that the ink savings is phenomenal. With that big print job and another pretty big job, I more than paid for the printer in the first week I had it with the ink savings.
This is the first machine I got from Amazon. I checked out prices at the stores and found that Amazon was a lot cheaper. I received it in the time that was stated and set it up and was sewing within 20 mins. I have been sewing for over 30 year and sewing all kinds of things, kids clothes, clothes for myself and other adults and house hold items. This is the machine to get, am thinking of ordering another one, just for back up. If you are looking for a machine to replace the one you have or thinking of getting one to start out...this is the one.