L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.
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Great item! I bought these to use upnorth, as we have an outhouse, not indoor plumbing. They get pretty bright, and light the way just fine. I was really interested in the all weather selling point. We usually go up in the summer and fall, so it'd be nice to just stick these in the ground and leave them. Hopefully they last! They look like they're up for our wisconsin winter though! Durable and tough. If anything changes I'll be sure to update.
Now I bought this for my three year old son with the hope that I would move him away from using my phone and focus on something that is educational.( Background note, my son has been using the computer since he was 1 1/2 years so he knows his way around technology.)
Smells great, but I don't have the oven clean yet. Does take off the top layer. Too afraid to use the clean oven function on my range so I'll keep trying. This is kind of expensive to use. Don't know if I'd order it again. Smell is terrific though and not caustic.