L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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    Pretty cool design , but leaves lots of finger prints that is my main issue with this case , another problem I found is that the bottom part where connnect to the charger is very sharp and is hard to hold the phone with one hand , I usually put my pinky finger as a support to hold it and use it if have my other hand busy but this makes my finger hurt .

  • C. Kirschner - Le Creuset 5'1/2 Qt

    This is a fabulous kitchen staple to have. The size is perfect for most dishes. I waited years to get it because I thought it too heavy and expensive. I am not strong or young but the handles on the pieces make it fine to handle. I should be giving away things to my kids but love this cookware and finally bought it. Most of the time I cook for my husband and me but often enough for company too. Julia's Chicken with mushrooms and vegetables, the best I have made. Pasta sauce to rave reviews. Beef great. Going back to Julia Child Recipes and Cook's Slow and Easy Recipes. By the way I live near outlets and promptly drove down and bought the 3-1/2 Casserole in Yellow, the Soup Pot was 1/2 off and got that in Kiwi and the 2'1/2 Qt in Flame for 1/2 off the outlet price with a coupon. The colors are delicious and take me away to the south of France or Tuscany. It's a joy to cook with. You can get it on special sometimes from dept stores which is about the outlet price. Cooking is love. Life is short. So I leave less to my kids but they can divvy up the cookware. You won't be sorry. PS I just saw the 7-1/2 qt at Costco for the outlet price.

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    My Mazda 6i at 60K miles started to have a rough idle whenever I would stop at a red light (the revs would oscillate and eventually settle at 750RPM, although it made the car do some nasty vibrations and would stall it out once in a while). I assumed it was either one of the sensors or throttle control but came across this product and figured it was worth a shot before I started to disassemble my engine.