L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.
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Country: 209.188.90.168, North America, US
City: -87.6272 Illinois, United States
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This has to be the worst program ever created. Never have I seen anything run so slow. Every task that is run not only takes a obscene amount of time (eg. running a full system scan takes an hour+, a quick scan takes 10-15 minutes and then sits at 98% for an additional 30 minutes. I finally have to reboot my computer because when it seems nothing is happening hitting cancel does nothing either). I keep getting a prompt from Windows saying I have no active security system even though McAfee says it is on. Once I tried to reinstall the program when this happened and you have to go thru the miserable McAfee customer service (good luck - give yourself at least 3+ hours) only to find out that they have to reinstall from there. They must take over your computer to do so ;-)! This IS NOT NORTON where you simply reinstall from the key you have. Everything about this program is miserable. So fed up, I bought Norton again after using McAfee for only (2) months. Awful, awful program. Everything on Norton takes a sew seconds to no more than < 5 minutes. Finally, every task you run on McAfee slows down your computer to a grinding halt. I was a FOOL to try something new.