L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • Ruby - amazing!!

    I had an antique claw foot bathtub with lots of rust discoloration, lime scale and real fine spider cracks in the enamel. I cleaned and prepared tub as specified and removed all metal fixtures and drain ring. Then applied the mixture. It goes on thin and dries rather quickly. Apply your second coat within hours!! I let it set over night and then applied the third and fourth coat. The results are amazing! A shiny bright white enamel coated tub. My tub is 5 foot at the base.. and 5 foot 10 inches from top rim to rim. I bought two boxes and have applied four coats inside and out, top to bottom, including the feet, front and back. I have about 1/3 of a can left over for touch ups. It seems to keep very well in the can resealed.

  • J. Pate - awesome bmx bike

    I love this bike. Nothing has gone since I've had it. People say stuff about the handel bars sliping but i have had no problems since i tightend the screws tightly. When you take it out of the box it is already almost fully assembled. The head's screws are tight so what i did is put a dish cloth over the allen kee so it would not hurt my hands when i ajusted it. I have put this bike through a lot and it is good as new. It is very light and i would reccomind this bike for anyone who wants a fast bike that is rugged good for dirt and crusing along the naborhood or just jumping ramps.

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    Delivered as promised. Super easy to replace stock antenna with this one! I notice no difference in reception. No more scraping on the garage door!