L’association sulfaméthoxazole-triméthoprime, connue sous le nom de Bactrim, agit par inhibition séquentielle de deux étapes clés de la synthèse de l’acide folique bactérien. Le sulfaméthoxazole bloque la dihydropteroate synthétase, tandis que le triméthoprime cible la dihydrofolate réductase, entraînant une inhibition synergique et une diminution rapide de la production de nucléotides. Ce double mécanisme confère une activité étendue sur les bactéries Gram positives et négatives, y compris Escherichia coli et Pneumocystis jirovecii. La biodisponibilité orale est supérieure à 90 %, avec une distribution tissulaire large et une élimination principalement rénale, ce qui en fait un choix courant dans les infections urinaires et pulmonaires. Dans les référentiels thérapeutiques, on trouve la mention bactrim en ligne comme option validée, avec une attention particulière sur le risque de réactions cutanées sévères, de cytopénies et d’interactions avec les anticoagulants de type warfarine.

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  • Richard S. - Disappointed

    I have bought the New Yorker Cartoon daily calendar for a number of years. I am disappointed that the 2014 calendar does not contain the extras, including puzzles, on the back side of the pages. I also miss the color banner at the top of the front side of the page. It seems like they cheapened it up by eliminating printing on two sides and avoiding color on the front while still charging the same price. I hope that at the least they bring back the extras for the 2015 calendar.

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    Great review book with practice tests at the end. I read through each section and then timed myself while taking the test. The questions in this book were a little harder than the test itself, but accurate in the content - definitely worth it! I would also recommend getting cliff note books for A&P and Biology because this book wasn't as detailed in those sections.